Canadian Pharmacy Discourages the
Use of New Blood Thinner Drug
An advisory panel to the U.S.
Food and Drug Administration on Wednesday voted against a new use of a new
blood thinner, Xarelto, to cut the risk of potentially lethal clots in people
with acute coronary syndrome. An advisory panel to the U.S. Food and Drug
Administration on Wednesday voted against a new use of a new blood thinner,
Xarelto, to cut the risk of potentially lethal clots in people with acute
coronary syndrome. To buy Warfarin is still one of the safest and most
effective moves when it comesto blood thinning medications. Xarelto (rivaroxaban)
is one of a new class of blood thinners that has been developed to overcome
some of the problems that exist with the standard treatment, warfarin
(Coumadin), which requires constant dose monitoring. The effectiveness of
generic Warfarin also can bealtered by certain foods and other medications.
Xarelto is already approved for use
by those with atrial fibrillation (irregular heartbeat) and by people who are
having hip- or knee-replacement surgery.Xarelto is a Dangerous Medicine
"What is not reflected in
the sponsor's analysis are minor bleeding events," FDA reviewer Dr. Karen
Hicks wrote in the briefing documents. "While it is true that these
bleeding events typically do not lead to death or irreversible harm, these events
may represent the biggest problem for both patients and health care providers
if rivaroxaban is approved." "While reductions in
[cardiovascular] death still trump these bleeding events, if rivaroxaban is
approved, we should expect a number of bleeding events that will require
medical attention," Hicks wrote. "Carefully selecting patients for
rivaroxaban therapy will be necessary to mitigate these bleeding risks." In
research presented at the American Stroke Association's International Stroke Conference
in New Orleans in February, Australian doctors followed more than 14,000 people
who took either Xarelto or warfarin for a median of two years. Of those
patients, 136 had bleeding in the brain.
People who took Xarelto --
and suffered from the most common type of atrial fibrillation and didn't have
heart valve damage -- were about one-third less likely to experience bleeding
in the brain than those who took warfarin, the investigators found. Canadian
pharmacy encourages doctors and patients to decide wisely when it comes to
choosing the right drug.
Blood is a specialized bodily fluid in animals
that delivers necessary substances such as nutrients and oxygen to the cells
and transports metabolic waste products away from those same cells.In
vertebrates, it is composed of blood cells suspended in a liquid called blood
plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by
volume), and contains dissipated proteins,glucose, mineral ions, hormones,
carbon dioxide (plasma being the main medium for excretory product
transportation), and blood cells themselves. Albumin is the main protein in
plasma, and it functions to regulate the colloidal osmotic pressure of blood.
The blood cells are mainly red blood cells (also called RBCs or erythrocytes)
and white blood cells, including leukocytes and platelets. The most abundant
cells in vertebrate blood are red blood cells.